Synthesis, Spectroscopic and in-Vitro Antifungal Studies of Drug Based Mixed Ligand Complexes

G. R. Chauhan^¹, G. J. Kharadi^² and K. D. Patel^¹*

¹Sophisticated Instrumentation Centre for Applied Research & Testing (SICART), Vallabh Vidyanagar, Gujarat India.

^¹*Department of Chemistry, V.P. and R.P.T.P. Science College, Vallabh Vidyanagar - 388 120 India.

^²Government Science College, Department of Chemistry, Gandhinagar, Gujarat India.

ABSTRACT:

The mixed-ligand complexes of various metal(II) with 5-chloro-7-iodo-8-hydroxyquinoline (Clioquinol) and 5-(methoxymethyl-8-quinolinol) (MMQ) were prepared. The structure of mixed-ligand complexes was investigated using spectral, physicochemical, elemental analyses and thermal studies. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared complexes. The ligands, metal salts, complexes, control and standard drug were tested for their in-vitro antifungal. The metal complexes exhibit good activity against fungal strains compared with parental compounds and moderate compared with the standard drug (Clioquinol).

KEYWORDS:

In-vitro antifungal activity; mixed-ligand complexes; spectral studies; magnetic moment

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Copy the following to cite this article: Chauhan G. R, Kharadi G. J, Patel K. D. Synthesis, Spectroscopic and in-Vitro Antifungal Studies of Drug Based Mixed Ligand Complexes. Orient J Chem 2010;26(4).

Copy the following to cite this URL: Chauhan G. R, Kharadi G. J, Patel K. D. Synthesis, Spectroscopic and in-Vitro Antifungal Studies of Drug Based Mixed Ligand Complexes. Orient J Chem 2010;26(4). Available from: http://www.orientjchem.org/?p=23979