Spectrophotometric Determination of Trace Amount of some Aromatic Amines in Pharmaceutical Formulations, Wastewater and Biological Fluids

K.C. Srinivasa Murthy

Department of Chemistry, R.L. Jalappa Institute of Technology, Kodigehalli, Doddaballapur-561 203, India.

ABSTRACT:

A simple, accurate, sensitive and rapid method for the determination of some aromatic amines in either the pure form or in pharmaceutical formulation or in biological fluids or in waste water sample is proposed. The method is based on the formation of colored compounds with sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium bromide in alkaline medium. Beer’s law of colored species is obeyed in the range of concentration of 0.5 – 24 µg ml-1. The molar absorptivity was found to be in the range of 3.7504x103 – 1.1180x104 l mol-1 cm-1. Results obtained by using the proposed method for various pharmaceutical preparations compare favorably with those obtained by the official method.

KEYWORDS:

Aromatic amines; Pharmaceutical formulations; Waste water and Biological fluids

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Copy the following to cite this article: Murthy K, C, S. Spectrophotometric Determination of Trace Amount of some Aromatic Amines in Pharmaceutical Formulations, Wastewater and Biological Fluids . Orient J Chem 2010;26(4).

Copy the following to cite this URL: Murthy K, C, S. Spectrophotometric Determination of Trace Amount of some Aromatic Amines in Pharmaceutical Formulations, Wastewater and Biological Fluids . Orient J Chem 2010;26(4). Available from: http://www.orientjchem.org/?p=23948