Spectrophotometric methods for the determination of Rosuvastatin

G.VINDYA RAO*, M.SHAIBA, P.BHARGAVI, T. DINESH KUMAR and CH.B. SWETHAPRIYA

K.V.S.R.Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada - 520 010 (India).

ABSTRACT:

Three simple and sensitive spectrophotometric methods have been developed for the estimation of Rosuvastatin in bulk and pharmaceutical dosage forms. Method A is based on oxidation followed by complex formation of the drug with 2, 5 dihydroxy 3, 6 dichloro 1, 4 benzoquinone (chloralinic acid λmax 530 nm). The absorbance of the colored species is measured against the corresponding reagent blank at 530nm. Method B is based on salt formation of the drug with picric acid (λmax 440nm). Method C is based on oxidation followed by complex formation of the drug with potassium permanganate (KMnO4 λmax 410nm). These methods have been statistically evaluated and found to be precise and accurate.

KEYWORDS:

Spectrophotometric; Rosuvastatin

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Copy the following to cite this article: RAO G. V, SHAIBA M, BHARGAVI P, KUMAR T. D, SWETHAPRIYA C. B. Spectrophotometric methods for the determination of Rosuvastatin. Orient J Chem 2010;26(3).

Copy the following to cite this URL: RAO G. V, SHAIBA M, BHARGAVI P, KUMAR T. D, SWETHAPRIYA C. B. Spectrophotometric methods for the determination of Rosuvastatin. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=29700