Influence of Sodium Starch Glycolate, Cros Carmellose Sodium and Cros Povidone on Disintegration of Directly Compressed Dispersible Tablets of Avipathi Choorna

J. S.Venkatesh¹,C. Nagesh¹, M. M. Shankaraiah¹,Nitin Mahurkar

¹Department of Pharmaceutics, S. C. S. College of Pharmacy, Harapanahalli - 583 131 India. ²Department of Pharmacology, H. K. E.’s College of pharmacy, Gulberga, Karnataka India.

ABSTRACT:

Formulation of ayurvedic powder preparations into tablets may increase dosage uniformity. Application of direct compression method to ayurvedic preparations can be regarded as a major advance. In the present study, dispersible tablets of avipathi choorna were prepared by direct compression method. Avipathi choorna was subjected to pre formulation studies to test the suitability of direct compression method and appropriate formulations were developed. These formulations were further evaluated for hardness, friability, weight variation, disintegration tests and stability studies. Attempts were made to get minimum possible disintegration time by varying the concentrations of sodium starch glycolate, cros carmellose, cros povidone and starch. It was found that, use of mixture of disintegrating and super disintegrating agents was highly useful in the formulation of dispersible tablets of avipathi choorna. The study further revealed the usefulness of direct compression method to formulate dispersible tablets of ayurvedic preparations.

KEYWORDS:

Avipathi choorna; dispersible tablets; direct compression; super disintegrants

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Copy the following to cite this article: Venkatesh J. S, Nagesh C, Shankaraiah M. M, Nitin M. ahurkar N. Influence of Sodium Starch Glycolate, Cros Carmellose Sodium and Cros Povidone on Disintegration of Directly Compressed Dispersible Tablets of Avipathi Choorna. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Venkatesh J. S, Nagesh C, Shankaraiah M. M, Nitin M. ahurkar N. Influence of Sodium Starch Glycolate, Cros Carmellose Sodium and Cros Povidone on Disintegration of Directly Compressed Dispersible Tablets of Avipathi Choorna. Orient J Chem 2008;24(2). Available from: http://www.orientjchem.org/?p=23928