Synthesis of Some New 1,2,5- Substituted Benzimidazole Derivatives and Their Pharmacological Activity

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Reaction of ortho phenylenediamine 1 with various organic acids yielded 2-substituted benzimidazole derivatives 2 which were further treated with nitric acid and sulphuric acid to afford 5-nitro-2-substituted benzimdazoles 3. Coupling of this compound with halogenated beta picoline 5 yielded the title compounds. The structures of synthesized compounds were elucidated mainly by spectral evidence. All the compounds were screened for their anti-inflammatory and anti-convulsant potential. The compounds exhibited moderate to significant activities.

Synthesis; benzimidazoles; anti-inflammatory activity; anti-convulasant activity