ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of Some New 1,2,5- Substituted Benzimidazole Derivatives and Their Pharmacological Activity

Volume 24, Number 1

Jitender Singh1* and Dharam Pal Pathak2    

1Lord Shiva College of Pharmacy, Sirsa -125 055 India. 2Delhi Institute of Pharmaceutical Sciences and Drug Research, Delhi India.

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ABSTRACT:

Reaction of ortho phenylenediamine 1 with various organic acids yielded 2-substituted benzimidazole derivatives 2 which were further treated with nitric acid and sulphuric acid to afford 5-nitro-2-substituted benzimdazoles 3. Coupling of this compound with halogenated beta picoline 5 yielded the title compounds. The structures of synthesized compounds were elucidated mainly by spectral evidence. All the compounds were screened for their anti-inflammatory and anti-convulsant potential. The compounds exhibited moderate to significant activities.

KEYWORDS:

Synthesis; benzimidazoles; anti-inflammatory activity; anti-convulasant activity

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Singh J, Pathak D. P. ynthesis of Some New 1,2,5- Substituted Benzimidazole Derivatives and Their Pharmacological Activity. Orient J Chem 2008;24(1).

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Singh J, Pathak D. P. ynthesis of Some New 1,2,5- Substituted Benzimidazole Derivatives and Their Pharmacological Activity. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23053

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