Synthesis and Antifungal Activity of 2-(4’substitutedanilinosydnon-3’-Yl) Pyridines

T. Chadra; S. K. Bhati; Preeti Yadav; R. C. Agarwal

Article | Open Access

Synthesis and Antifungal Activity of 2-(4’substitutedanilinosydnon-3’-Yl) Pyridines

T. Chadra¹, S. K. Bhati¹, Preeti Yadav², and R. C. Agarwal²

¹Department of Pharmacology, LLRM Medical College, Meerut India. ²Hindu College, Moradabad India. ³K. G. College, Moradabad India.

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ABSTRACT:

2-(sydnon-3'-y1) Pyridine³ was synthesized by heating acetic anhydride with 2-N-Nitroso-N- (pyridin-(2'-yl)] imino acetic acid². The Bromination of compound³ in the formation of 2-(4' bromosydnon-3'-yl) Pyridine4. The final componds 2-[4' substituted anilino sydon-3'- yl) pydines (5a-5e) were obtained by mannich reaction of compounds4 was substituted aromatic animes. The structure of these compounds have been confirmed by IR,‘H NMR and mass analysis. The newly synthesized compunds have been evaluated for their antifungal activity compound (5a) was found to be equipotent to the standards against C. albicans, C. Parapsilosis 22019, A niger, and A. flavus.

KEYWORDS:

Pyridine derivatives; antifungal activity