ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Simultaneous Estimation of Simvastatin and Ezetimibe by Rp-Hplc in Pure and Pharmaceutical Dosage Form

B. Neelima1, P. Ravi Kumar1, M. Murali Krishna1,V. Hima Bindu    

1University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003 India. 2Centrer for Environment, Institute of Science and Technology, Jawaharlal Nehru Technical University, Hyderabad-500 085 India.

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ABSTRACT:

A simple, precise and rapid RP-HPLC method was developed for the simultaneous determination of simvastatin and ezetimibe in combined pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of acetonitrile: methanol: buffer (triethylamine pH-3) in the ratio 15:45:40 and detection was done at 240 nm using external standard method as quantitation. The linearity range of simvastatin and ezetimibe were 0.5 to 20 μg/ml. The intra-day and inter-day precision were in the range of 1.02-1.43 and 0.53-0.94 for simvastatin, 0.24-1.29 and 0.93-1.32 for ezetimibe.

KEYWORDS:

Simvastatin; Ezetimibe; Tablets; RP-HPLC

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Neelima B, Kumar P. R, Krishna M. M, Bindu V. H. Simultaneous Estimation of Simvastatin and Ezetimibe by Rp-Hplc in Pure and Pharmaceutical Dosage Form. Orient J Chem 2008;24(1).


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Neelima B, Kumar P. R, Krishna M. M, Bindu V. H. Simultaneous Estimation of Simvastatin and Ezetimibe by Rp-Hplc in Pure and Pharmaceutical Dosage Form. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23198



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