Selective Hydrogenation of 2 Phenoxy Aniline with Various Catalysts to Make The Drug Intermediate’s Manufacturing Environmentally Viable

V. B. Kotwal¹, J. G. Chandorkar²*, M. K. Dongare³ and C. V. Rode⁴

¹Aarti Drugs Ltd., Mumbai - 400 016 India.

²Group Principal Scientist, Innovassynth Tech. (I) Ltd., Khopoli - 410 203. Dist. Raigad India.

³Head of Department Catalysis Department, National Chemical Laboratory, Pune - 411 008 India.

4Catalysis Department National Chemical Laboratory, Pune - 411 008 India.

ABSTRACT:

Many catalysts are available which are claimed to have good Hydrogenation Catalytic capacity but catalyst like sulphur cast iron are not becoming suitable as far as solid waste is concern. In the present study an attempt has been made to study activity of three catalyst along with from sulfur as a traditional to compare the quality and quantity of the 2 phenoxy aniline and their effectiveness as far as waster reduction is concern. The study was to eliminate the waste which was from sulfur to make manufacturing process more envirofriendly and effective. Different concentrations of palladium on charcoal are studied and results are compared with the traditional catalysts. Reactions were carried out with keeping other parameters constant. This catalyst has showed significant reduction in the waster disposal without deviating stiochemistry of the reactions. The study revealed a considerable difference in waste disposals of the products. On comparison the concentration of catalysts the product is evaluated for the quality and quantity of the product.

KEYWORDS:

Hydrogenation; Palladium on charcoal; Platinum on Charcoal; Rany Nickel; Sulphur

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Copy the following to cite this article: Kotwal V. B, Chandorkar J. G, Dongare M. K, Rode C. V. Selective Hydrogenation of 2 Phenoxy Aniline with Various Catalysts to Make The Drug Intermediate’s Manufacturing Environmentally Viable. Orient J Chem 2008;24(1).

Copy the following to cite this URL: Kotwal V. B, Chandorkar J. G, Dongare M. K, Rode C. V. Selective Hydrogenation of 2 Phenoxy Aniline with Various Catalysts to Make The Drug Intermediate’s Manufacturing Environmentally Viable. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23279