Formulation and Antibacterial Evaluation of Some Novel S-Triazine Based Chalcones and Their Derivatives

Anjani Solankee, Sejal Solankee, and Ghanshyam Patel

Department of Chemsitry, B. K. M. Science College, Valsad - 396 001 India.

ABSTRACT:

Some new chalcones, 2-(4'-chlorophenylamino)-4-(4'-flurophenylamino)-6-[4'-3{3-(substituted phenyl/2-thienyl/2furanyl)-2""-propenon-1""-yl} phenylamino]-s-triazine (6a-e) have been acheived by the reaction between 2-(4'-chlorophenylamino)-4-(4'-flurophenylamino)-6-(4'-acetylphenylamino)-s-triazine (5) and differentt aromatic and heterocycli aldehydes, which on cyclisation with phenyl hydrazine hydrochloride in the presence of alkali give phenyl pyrazolines (7a-e). Chalcones (6a-e) on cyclisation with malononitrile in the presence of ammonium acetate give cyanopyridines (8a-e). The characterization of newly synthesized compounds has been done on the basis of IR, ¹H NMR spectral data as well as elemental analysis. The compounds have been evaluated for antibacterial activity against E. coli (MTCC 443), S. paratyphi-B (MTCC 733), S. aureus (MTCC 96) and B. Subtilis (MTCC 441)"

KEYWORDS:

Chalcones; pyrazolines; cyanopyridines; spectral data; antibacterial activity

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Copy the following to cite this article: Solankee A, Solankee S, Patel G. Formulation and Antibacterial Evaluation of Some Novel S-Triazine Based Chalcones and Their Derivatives. Orient J Chem 2008;24(1).

Copy the following to cite this URL: Solankee A, Solankee S, Patel G. Formulation and Antibacterial Evaluation of Some Novel S-Triazine Based Chalcones and Their Derivatives. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23300