Synthesis of Isomeric Groups of Substituted Quinazolones for Their Antibacterial and Anti-Inflammatory Activities

A. Thirugnana Sambanthan*¹, Basavaraj Hulkoti² and A. J. Rajamma³

¹Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy, Bangalore-10 (India) ²Department of Pharmacology, K.L.E.S’s College of Pharmacy, Bangalore-10 (India) ³Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Bangalore-10 (India)

A series of isomeric groups of 2,3 disubstituted quinazolones were synthesized from the starting material 2-methyl benzoxacin-4-one, which was prepared by refluxation of anthranilic acid with acetic anhydride. 2 -methyl benzoxacin-4-one was reacted with various chloro substituted amino benzoic acids to get 2-methyl-3-(substituted aryl) quinazolones which were made to react with various p-substituted aromatic aldehydes to obtain 2-(substituted styryl)-3-(substituted aryl)-quinazolones. The synthesized compounds were purified and characterized by IR and NMR spectroscopy. All the isomeric compounds screened for anti-inflammatory and antibacterial activity have shown significant activity compared to their standard.

Benzoxazin-4-one; chloro amino benzoic acids; isomeric quinazolones antiinflammatory; antibacterial activity