Synthesis of New A-Arylidine-3-Aryloxymethyl-5-Substituted -S-Triazolo-[3, 4-B][1, 3, 4]-Thiadiazoles and Evaluation of Their Biological Activity

P. Srinivasa rao1, R. H. Udupi1 and Y. Rajendraprasad2*

¹PG Department of Pharmaceutical Chemistry, N.E.T. Pharmacy College, Raichur - 584 103 (India) ²Pharmaceutical Chemistry Laboratories, University College of Pharmaceutical Sciences, Andhra University, Waltair - 530 003 (India)

Certain new 3,5-disubstituted-s-triazolo-[3,4-b] [1,3,4]-thiadiazoles (4a1-a16) and 3,5-disubstituted-6-thio-s-triazolo-[3,4-b] [1,3,4]-thiadiazoles (4b1-b16) were prepared in excellent yield from their respective mercapto triazoles (3a1-a16 ) and (3b1-b16) . The triazolo thiadiazoles containing active methylene groups (4a1-a16) and (4b1-b16) on condensation with anisaldehyde resulted the required title compounds (5a1-a16) and (5b1-b16). The structures of newly synthesized compounds have been established on the basis of elemental analysis and spectral data. Few compounds showed significant antibacterial, antifungal and other biological activities.

Biological activity;a-arylidine-3-aryloxymethyl-5-substituted-s -triazolo-[3, 4-b][1; 3; 4]-thiadiazoles