Synthesis and Characterization of Some Carboxamides of 2-Amino-4- Phenyl Thiazole as Antimicrobial Agents

K. N. Venugopala; Gopal Krishna Rao; P. N. Sanjay PaI; Gorle Lakshmi Ganesh

Article | Open Access

Synthesis and Characterization of Some Carboxamides of 2-Amino-4- Phenyl Thiazole as Antimicrobial Agents

K. N. Venugopala*, Gopal Krishna Rao, P. N. Sanjay PaI1 and Gorle Lakshmi Ganesh

¹Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore - 560 027 (India) ²Department of Quality Assurance, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore - 560 027 (India)

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ABSTRACT:

A series of carboxamides of 2-amino-4-phenyl thiazole (3a-h) and (4) were synthesized, purified and characterized on the basis of spectral data such as IR, 1H-NMR, mass spectra and elemental analysis. The test samples were subjected to antibacterial activity by agar cup plate method. Out of the nine compounds tested, chloro and methyl analogs showed significant antibacterial activity.

KEYWORDS:

Carboxamides; phenyl aminothiazole; antimicrobial activity