Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones
Rajendra K. Saini1, Yogesh C. Joshi,1 Neetu Kumari,1 Usha Baloda1 And Pramila Joshi2
1Department of Chemistry, University of Rajasthan, Jaipur - 302 004 (India) 2S.S. Jain Subodh P.G. College, Jaipur (India)
Condensation of various diketone (la-1f) with hydrazine hydrate in absolute ethanol led to the synthesis of 3-substituted phenyl-4-(8-quinolinesulfonyl)-5-(1,3-benzodioxol-5-yl)-1H-pyrazole. Structure of Newly synthesized Pyrazole derivative were established on the basis of spectral studies viz : IR 1H NMR 13C NMR. Newly synthesized compounds (2a-2f) were screened for their antimicrobial activity against Alternaria brassiciola, Fusariumudam, Staphylococcus, and Lactobacillus.
KEYWORDS:1;3-Diketone; hydrazine hydrate; Pyrazole; absolute ethanol; antimicrobial screening
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| Copy the following to cite this article: Saini R. K, Joshi Y. C, Kumari N, Baloda U, Joshi P. Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones. Orient J Chem 2007;23(2). |
| Copy the following to cite this URL: Saini R. K, Joshi Y. C, Kumari N, Baloda U, Joshi P. Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones. Orient J Chem 2007;23(2). Available from: http://www.orientjchem.org/?p=20267 |
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