ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Microwave Assisted Synthesis and Antimicrobial Activity of 7-Chloro-6-Fluoro-2-(Substituted Aromatic Sulphonyl Hydrazino) Benzothiazoles

Volume 23, Number 2

S. M. Hipparagi1, U. K. Majumder2, B. Parikshit1 M. Geethavani1 and V. Suresh Kumar1

1Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy,2nd Block, Rajajinagar, Bangalore - 560 010 (India) 2Pharmaceutical Technology Department, Jadhavpur University, Kolkata - 700 032 (India)

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ABSTRACT:

In the present work prepared 7-chloro-6-fluoro-benzothiazole-2-ylamine(P) from 3-chloro-4-fluoro-phenylamine. 7-chloro-6-fluoro-benzothiazole-2-ylamine on treatment with hydrazine hydrate in microwave oven for 6minutes to get 7-chloro-6-fluoro-benzothiazol-2-yl-hydrazine(PB) which on treatment with different substituted aromatic sulphonyl compounds yields the title compounds(PB1-9). Various compound and their derivatives were prepared and conformed by IR, NMR and Mass spectra. Antimicrobial study shown that synthesized compounds have moderate activity.

KEYWORDS:

Benzothiazole; Substituted sulphonyl chlorides; antimicrobial activity

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Hipparagi S. M, Majumder U. K, Parikshit B, Geethavani M, Kumar V. S. Microwave Assisted Synthesis and Antimicrobial Activity of 7-Chloro-6-Fluoro-2-(Substituted Aromatic Sulphonyl Hydrazino) Benzothiazoles. Orient J Chem 2007;23(2).

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Hipparagi S. M, Majumder U. K, Parikshit B, Geethavani M, Kumar V. S. Microwave Assisted Synthesis and Antimicrobial Activity of 7-Chloro-6-Fluoro-2-(Substituted Aromatic Sulphonyl Hydrazino) Benzothiazoles. Orient J Chem 2007;23(2). Available from: http://www.orientjchem.org/?p=20239

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