Andromedane Type Derivatives from Roots of Arnebia Nobilis

Ramidi Ramachandrum, Mohammad Ali* and Showkat R. Mir

Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), P.O. Hamdard Nagar, New Delhi - 110 062 (India)

A series of aromedane-type diterpenes, namely andromedanoyl-20-heptanoate A (1), B (2), C (3), D (6), E (7), F (8), andromedanoyl-20-nonanoate (4)and andromedanoyl-20-undecanoate (5) have been isolated from the roots of Arnebia nobilis and the structures of all these new phytoconstituents have been formulated as 11(14)-endocyclic-andromeda-9(11)-en-20-oxy-1'-heptanoate (1); andromeda-9(11),13(16)-diene-20-oxy-1'-heptanoate (2); 11(14), 11(16), 1(18)-endotricyclic-andromedane-20-oxy-1'-heptanoate (3); 11(14), 14(17)-endobicyclic-andromedan-12-en-20-oxy-1'-nonanoate (4); 11(14), 14(17)-endobicyclic-andromeda-12-en-20-oxy-1'-undecanoate (5); 1(18), 11(15)-endobicyclic-andromeda-15-en-20-oxy-1'-heptanoate(6); 6(15)-cyclic-andromeda-12-en-20-oxy-hept-6'-en-1'-oate (7); 1(18), 11(15)-endobicyclic-andromeda-13(16)-en-20-oxy-1'-heptanoate (8) on the basis of spectral data analyses and chemical means.

Arnebia nobilis; Andromedane-type diterpenes; Ratanjot; spectral data analyses