Synthesis, Characterization and Antimicrobial Activities of Some Furyl-Pyrazolyl Compounds

S. B. Pawar¹, S. N. Shelke¹, S. M. Sonawane¹, C .H. Gill² and B. K. Karale¹

¹P.G. Department of Chemistry, S.S.G.M. College, Kopargaon, Ahmednagar- 423 601 (India) ²Department of Chemistry, Dr. B. A. M. University, Aurangabad (India)

2-Hydroxy acetophenones 1 are treated with 3-furyl-2-yl-1-phenyl-1H- pyrazol-4 –carboxaldehyde 2 to get (2-hydroxy phenyl)-3(3-furyl-2-yl-1-Phenyl -1H- pyrazol -4-yl)-2-propen-1-ones 3. Compound 3 when treated with hydrazine hydrate gave 5(3-furyl-2-yl-1-phenyl-1H-pyrazol -4-yl)-3-(2-hydroxy phenyl)-4,5-dihydro-pyrazolines 4. Compound 3 when treated with catalytic amount of iodine in DMSO to get 2(3-furyl-2-yl-1-phenyl-1H-pyrazol-4-yl) chromones 5 and with CuCl2 in DMSO to get 2(3-furyl-2-yl-1-phenyl-1H-pyrazol-4-yl)-3-chloro chromones 6. Products obtained are characterized by IR, 1HNMR and mass spectra. Some of the compounds 5 are screened for their antimicrobial activity.

Antimicrobial activity; Furyl-pyrazolyl compounds