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Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones

Volume 23, Number 1

Rajendra K. Saini1, Yogesh C.Joshi2, Neetu Kumari1,Usha Baloda1 And Prami1

1Department of Chemistry, University of Rajasthan, Jaipur - 302 004 (India) 2S.S. Jain Subodh P.G. College, Jaipur (India)

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ABSTRACT:

Condensation of various diketone (la-1f) with hydrazine hydrate in absolute ethanol led to the synthesis of 3-substituted phenyl-4-(8-quinolinesulfonyl)-5-(1,3-benzodioxol-5-yl)-1H-pyrazole. Structure of Newly synthesized Pyrazole derivative were established on the basis of spectral studies viz : IR 1H NMR 13C NMR. Newly synthesized compounds (2a-2f) were screened for their antimicrobial activity against Alternaria brassiciola, Fusariumudam, Staphylococcus, and Lactobacillus.

KEYWORDS:

1,3-Diketone; hydrazine hydrate; Pyrazole; absolute ethanol; antimicrobial screening

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Saini R. K, Joshi Y. C, Kumari N, Baloda U. Prami. Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones. Orient J Chem 2007;23(1).

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Saini R. K, Joshi Y. C, Kumari N, Baloda U. Prami. Synthesis and Antimicrobial Screening of Novel 1H-Pyrazole Derivatives from 1,3-Diketones. Orient J Chem 2007;23(1). Available from: http://www.orientjchem.org/?p=19836

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