Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-Benzo[4,5]Thiazolo[2,3-C][1,2,4]Triazole
S. M.Hipparagi1, U. K. Majumder2, M. Vyavahare1*, P. Panpaliya3, K. Soni2, and L. V. G. Nar4
1Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy, Rajajinagar, Bangalore - 560 010 (India) 2Pharmaceutical Technology Department, Jadhavpur University, Kolkata - 700 032 (India) 3Nargund College of pharmacy, Dattaraynagar, Bangalore-560085 (India) 4Department of Chemistry. K.L.E.S’s S. Nijalingappa college, IInd Block, Rajaji Nagar Bangalore - 560 010 (India)
We synthesized 7-substituted-6-fluoro-benzothiazol-2-ylamine(M2) from 3-Chloro-4-fluoro phenylamine. 7-substituted-6-fluoro- benzothiazol-2-ylamine on treatment with hydrazine hydrate gives 7-substituted-6-fluoro-benzothiazol-2-yl-hydrazine(M3). And than prepared 8-substituted-7-fluoro-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole (MV1-5) by treating with triethyl orthoformate. The derivatives were synthesized by treating with various substituted aromatic amines. Antimicrobial study shows that synthesized compounds have moderate activity.
KEYWORDS:Benzothiazole; triazole; antimicrobial activity
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| Copy the following to cite this article: Hipparagi S. M, Majumder U. Vyavahare M. Panpaliya P, Soni K, Nar L. V. G. Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-Benzo[4,5]Thiazolo[2,3-C][1,2,4]Triazole. Orient J Chem 2007;23(1). |
| Copy the following to cite this URL: Hipparagi S. M, Majumder U. Vyavahare M. Panpaliya P, Soni K, Nar L. V. G. Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-Benzo[4,5]Thiazolo[2,3-C][1,2,4]Triazole. Orient J Chem 2007;23(1). Available from: http://www.orientjchem.org/?p=19840 |
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