Synthesis and Antimicrobial Activity of Pyrazine-2-Carboxylic Acid With Various Sulfonamide Derivatives

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2-{N4-[N1-(Substituted aryl) p-amino benzene sulfonamido] carbonyl} pyrazine (IIIa-k) and 2-{[N-(p-substituted benzene) sulfonamido] carbonyl} pyrazine (IVI-0) have been carried out by the condensation of pyrazine -2-carbonyl chloride (II) which in turn were prepared from various sulfonamides and pyrazine -2- carboxylic acid (I). The structures of new compounds have established on the basis of elemental analysis, IR and 1H-NMR spectral data. The synthesized compounds have been evaluated for their antibacterial and antifungal activity.

Study of sulphonamide derivatives