ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis and Anti-Tumour Activity of Some Indolizine-2-Carbonylamino Acid Derivatives

Volume 22, Number 1

Amardeep Ankalgi, Amit Kumar Das* and Mayukh Baidya

Krupanidhi College of Pharmacy, 5, Sarjapur Road, Koramangala, Bangalore - 560 034 (India)

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ABSTRACT:

Few amino acid derivatives of indolizine-2-carboxylic acid have been synthesized by converting of Indolizine-2-carboxylic acid to acyl chloride, followed by condensation with various amino acids. The starting material of Indolizine-2-carboxylic acid was prepared by aldol type condensation of ethyl bromopyruvate with รก-picoline. These synthesized compounds, indolizine-2-carbonylamino acid derivatives were screened for anti-tumour activity using Erhlich Ascites Carcinoma (EAC) Cell induced albino mice. The compounds IIIa and IIId showed significant anti-tumour activity, IIIb and IIIc were found to be moderately active and remaining were inactive.

KEYWORDS:

Indolizine-2-carboxylic acid; anti-tumour; amino acids

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Ankalgi A, Das A. K, Baidya M. Synthesis and Anti-Tumour Activity of Some Indolizine-2-Carbonylamino Acid Derivatives. Orient J Chem 2006;22(1).

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Abdalla N. A, El-Desoky T. I, Amrallah A. H, Hassan F. W. Potentiometric Studies on Some 6- Amino 2- Pyridyl Azo Dyes and Their Chelates. Orient J Chem 2006;22(1). Available from: http://www.orientjchem.org/?p=19352

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