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Synthesis and Evaluation of Some Amino Acid Analogues of Diclofenac As Prodrugs

Volume 17, Number 3

J. G. Asthana*, Mukesh Dua, Ashutosh Mishra and Satyendra Suryavanshi

Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar - 470 003 (India)

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ABSTRACT:

Diclofenac analogues as prodrug were synthesized and evaluated for antiinflammatory and analgesic activities. Hydrolysis studies of the prodrugs were performed in SGF and SIF. The synthesized compounds showed antiinflammatory and analgesic activity comparable to the parent drug.

KEYWORDS:

Amino acids; diclofenac as prodrugs

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Asthana J. G, Dua M, Mishra A, Suryavanshi S. Synthesis and Evaluation of Some Amino Acid Analogues of Diclofenac As Prodrugs. Orient J Chem 2001;17(3).


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Asthana J. G, Dua M, Mishra A, Suryavanshi S. Synthesis and Evaluation of Some Amino Acid Analogues of Diclofenac As Prodrugs. Orient J Chem 2001;17(3). Available from: http://www.orientjchem.org/?p=16499

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