Abstract

Manal M.Hamed¹, Samir M. El-Amin¹, Laila A. Refahy^1*, El-Sayed A. Soliman², Wafaa A. Mansour³, Hoda M. Abu Taleb⁴ and Eman A. Morsi¹

DOI : http://dx.doi.org/10.13005/ojc/310341

Anticancer and antiviral activity of methanol, chloroform and butanol extracts of Ulmus pravifolia were tested on three cytokines of the human ascites fluid, TNF-alpha, Interferons-gamma and NO.  Chloroform and butanol extracts showed a significant curative effect. Both butanol and chloroform extract undergo chromatographic fractionation to yield five compounds identified as Hederagenin 3-O-ß-D-glucopyranoside (1), Kaempferol 3-O-ß-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→2)-O-ß-D-glucopyranosyl-7-O-ß-D-glucopyranoside (2), 24-hydroxy-24-methylcycloartanol trans-ferulate (3),  lupeol caffeate (4) and Ulmicin D (5).  All compounds were isolated from the plant for the first time. The five compounds showed significant curative effect.

Ulmus pravfolia; antiviral; anticancer; cytokines; hepatitis C; hepatocellular carcinoma; TNF-alpha; Interferon-gamma; NO

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