Abstract

Synthesis, Characterisation, DFT Studies and Electrochemical and Biological Application Studies of a New Schiff Base Based on from Naphthalene-1, 8-Diamine and its Co(II), Ni(II), Cu(II) and Zn(II) Complexes

Geetha Thamaraichelvan and Santhi Sambamoorthy*

DOI : http://dx.doi.org/10.13005/ojc/400631

Abstract:

A new Schiff base 4,4’-((naphthalene-1,8-diylbis(azanylylidene))bis(methanylylidene)) diphenol (NDBDP) has been synthesized from 4-hydroxybenzaldehyde and 1,8-diaminonaphthalene and characterised by Infrared, Ultraviolet-Visible, Proton-1 Nuclear Magnetic Resonance, Carbon-13 Nuclear Magnetic Resonance and mass spectral studies. Further, the Schiff base has been complexated with Cobalt(II),Nickel(II),Copper(II) and Zinc(II). All the synthesised complexes are established as neutral complexes based on various spectral, analytical and magnetic behavioral studies. The redox property of all the metal Schiff base complexes have been explored through cyclic voltammetry analysis. Density Functional Theory (DFT) studies have been performed using GAUSSIAN09W program with B3LYP/6-31G (d,p) as the basis set to substantiate the structure of Schiff base NDBDP. The synthesized Schiff base and its transition metal complexes have been scrutinised for their biopotency namely antimicrobial, anti-inflammatory and antioxidant activities. The complex [Cu(NDBDP)₂] is found to possess high antioxidant activity. The cytotoxic behaviour of the [Cu(NDBDP)₂] complex was scrutinized in MCF-7 (human breast cancer cell lines) which indicate the moderate cytotoxic behaviour of the complex.

Keywords:

Anticancer; Antioxidant; Anti-inflammatory; Metal Complexes; Schiff base

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