Abstract

Vilas Vane¹, Ramesh Mokal¹, Usha Yashwante², Rohan Meshram²and Suresh Jadhavar^1*

DOI : http://dx.doi.org/10.13005/ojc/400419

The methodologies detail the steps for synthesizing a series of chalcones using a protic solvent and 4-fluoro-3-methylacetophenone (FMAA) along with substituted benzaldehydes. In the current investigation, we synthesized chalcone and tested in-silico and in-vitro evaluation. Tested in-vitro studies of both Gram-positive and Gram-negative bacteria for antimicrobial and antifungal activity using the disc-diffusion method. In-silicon study of all synthesized derivatives results demonstrated a good binding affinity with the target microorganism proteins, with some compounds displaying the best binding affinity, according to in-vitro research. When compound 1C interacted with the protein Glutaredoxin, it had a -5.43 Kcal/mol affinity. The best binding energies with the proteins UDP-3-O-[3-hydroxymyristoyl] N-acetyl glucosamine deacetylase, DNA gyrase, and dihydrofolate reductase were demonstrated by compound 1D, which has -6.3 Kcal/mol, -5.62 Kcal/mol, and -6.55 Kcal/mol, respectively.

4-Fluoro-3-methylacetophenone; In-Vitro; In-Silico; Grinding technique; Solvent-free synthesis; Ultrasonic synthesis

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