Abstract

Prasad D. Kadam¹, Ganpat R. Nagargoje², Abhay S. Bondge³, Kalimoddin I. Momin⁴, Sharad P. Panchgalle⁵ and Vijaykumar S. More⁶

DOI : http://dx.doi.org/10.13005/ojc/400423

In this research, we conducted the synthesis of derivatives (2a-c) derived from 4-fluoro-3-methylacetophenone (FMAP) (1) using aldol condensation with substituteddibromobenzaldehydes (a-c). The condensation process occurred in ethanol with the presence of a base, leading to the creation of chalcone derivatives (2a-c). These chalcones serve as crucial intermediates for the production of a diverse array of heterocyclic products. Upon reaction with hydrazine, pyrazol derivatives (3a-c) were obtained, while the use of hydroxylamine hydrochloride resulted in the formation of isoxazole (4a-c). Additionally, the reaction with urea produced oxazine derivatives (5a-c). We characterized all these compounds using spectral techniques, monitoring their reactions through TLC and measuring melting points. Subsequently, we assessed the biological activity of these compounds against two distinct bacterial strains.

Antifungal activities; Biological activity; Chalcone; Isoxzazole

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