Abstract

Gaman G. Barat, Mahesh R. Solanki^*

DOI : http://dx.doi.org/10.13005/ojc/400322

Heterocyclic compound such as quinazoline derivatives shows wide range of medicinal application in the area such as anticonvulsant, antitumor, antifungal, antimalaria, anti-hyperlipidemic and anti-inflammatory etc. activity because of these it shows great interest to study. In the presence study, we have synthesized triazole based quinazolinones by condensation reaction between α-methyl ketone and aromatic aldehydes under ethanol as the solvent to produced chalcones derivatives. This chalcone derivative have α, β-unsaturated part which is enhanced the reactivity of compound. Chalcone further reacted with 2-aminotriazole under alkali media in the presence of ethanol as the solvent to produced quinazolinone. This prepared compound has further possibility to modified at N atom upon reaction with halogen containing compound. Prepared quinazolinone were further treated with cyanuric chloride to increase heterocyclic part in the compound. Characterization of all synthesized product were done using spectroscopic techniques. All prepared compounds were screen for their biological evaluation against gram +ve and gram -ve bacteria.

-Aminotriazole; Antimicrobial activity; Cyanuric chloride; Quinazolinone

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