Abstract

Elda Surhaida Latif¹, Normah Awang^1*, Nur Rasyiqin Rasli¹, Daphne Wong Qiao Xuan¹, Noor Eszrezad Juferi², Nik Norhazrina Nik Mohd Kamil³, Asmah Hamid¹

DOI : http://dx.doi.org/10.13005/ojc/400203

The potential of Sphagnum sericeum (SS) moss extracts as an alternative treatment for childhood acute lymphoblastic leukaemia (ALL) was investigated in this study. Aqueous, methanol, and chloroform SS extracts were analyzed for phytochemical composition and cytotoxic effects on T-cell ALL lines (Jurkat and CCL-119). Results show that the S. sericeum aqueous extract (SSAE) yielded the highest percentage, followed by the methanol extract (SSME) and the chloroform extract (SSCE). Phytochemical analysis identified alkaloids, glycosides, and terpenoids in all extracts. SSME demonstrated significant cytotoxicity towards ALL cells, with the lowest IC50 values observed at 72 hours. Notably, SSME induced morphological changes, including blebbing and cell fragmentation after 6 hours, indicative of apoptosis and cell destruction. These findings suggest SSME's potential as a natural agent for treating paediatric ALL, offering a novel approach in cancer research and contributing insights into the phytochemical compounds and cytotoxic effects of S. sericeum extracts on T-ALL cell lines.

Acute lymphoblastic leukaemia; Cytotoxicity; Extraction yield; Phytochemical contents; Sphagnum sericeum;

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