Abstract

Parth Anilkumar Barot^*, Mohyuddin Abdulbhai Maradiya and Jabali J. Vora

DOI : http://dx.doi.org/10.13005/ojc/400219

The study investigated the formation of cobalt, nickel, and copper metal complexes by reacting metal chloride with the ligand pregabalin and the medication terbutaline. The complexes had the formula C20H40N2O7MCl2, where M = Co(II), Ni(II), and Cu(II). The analysis used elemental data, molar mass, and infrared (IR) spectrum studies. The IR frequencies of the ligand bands showed changes, indicating coordination with the metal ion. The study found that the ligands pregabalin and terbutaline exhibited bidentate properties of metal complexes. The research focused on how metal complexation affected the functionality of terbutaline and pregabalin complexes about Alzheimer's Disease (AD) and Parkinson's Disease (PD). The results demonstrated strong interactions with amino acids in the binding region of the targeted protein. The study suggested that zinc metal carboxylates with antioxidant and anticholinesterase properties could be beneficial in treating Alzheimer's diseases.

Alzheimer’s disease; Metal complexes; Molecular Docking; Pregabalin; Parkinson’s disease; Terbutaline

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