Abstract

Sandip U Agare¹, Mahesh P More¹, Sanjay P Tajane² and Tanuja V Kadre^1*

DOI : http://dx.doi.org/10.13005/ojc/400223

A set of novel acylated pyrazoline compounds 3(a-i) was prepared and structural elucidation was confirmed by using spectroscopic techniques such as 1H-NMR, FT-IR, and mass spectroscopy. Progress of the reaction was monitored by TLC. The synthesized set of acylated pyrazoline compounds 3(a-i) was evaluated for antimicrobial screening which reveals that these compounds have interesting properties. The discs diffusion method was utilized to perform in-vitro antimicrobial activity of pyrazoline derivatives 3(a-i) against Escherichia coli (MCC-2412), Staphylococcus aureus (MCC-2408), B. subtilis (MCC-2010), P. aeruginosa (MCC-2080), Saccharomyces cerevisiae (MCC-1033), and Candida albicans (MCC-1439).Some of the acylated molecules such as 3c, 3d, 3g and 3e emerged as excellent designs represents comparable or higher antimicrobial activities concerning standard drug candidates.

Antifungal; Antibacterial; Acylated Pyrazoline; Antimicrobial; Pyrazoline

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