Abstract

Divya Singh^{1, 2*}, Rajeev Kharb¹ and Satish Kumar Sharma³

DOI : http://dx.doi.org/10.13005/ojc/400113

Inflammation is a complex physiological response that can lead to various health issues. The development of effective anti-inflammatory agents is crucial for managing inflammatory conditions. This study focused on synthesizing and evaluating Schiff's base Indole derivatives for their anti-inflammatory potential. Among several synthesized compounds, C1IN, C2IN, C3IN, C7IN, C8IN, and C11IN demonstrated substantial reductions in paw edema and levels of cytokines of inflammation such as IL-1β and TNF-α. In-silico analysis and molecular docking studies further supported the observed effects, indicating potential interactions with TNF-α. The study highlights the therapeutic potential of Schiff's base Indole derivatives in mitigating inflammatory responses. Hence, Schiff's base Indole derivatives present a novel avenue for future research and the potential development of anti-inflammatory drugs.

Computational analysis; Docking Study; Inflammation; Indole Derivatives; Molecular docking analysis; Schiff’s Base; Spectroscopy Analysis

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