Abstract

S. Chitrarasu¹, A. Selvam², M. Yogapriya^1*, K. Boopathi³ and K.Selvapriya⁴

DOI : http://dx.doi.org/10.13005/ojc/390523

Motor neuron disease (MND) has become the most widespread neurodegenerative disease, like ALS, AD, and PD, affecting millions of human beings worldwide. Among these, ALS disease plays a major role in MND. The metal oxides have an essential role in neurodegenerative diseases. Cerium oxide nanoparticles have received a lot of attention in recent years as a potential future remedy for treating a variety of problems due to their redox activity, free radical scavenging capabilities, biofilm suppression, and other features. We are using molecular docking experiments to better understand the interaction of transition metal oxides (CeO2) with mutated and Non-mutated SOD1 proteins. Through the use of molecular docking studies, the structural relationship between amino acids, binding energy, and ligand efficiency was investigated. Auto-dock analysis also reveals that the CeO2 nanoparticle has significant binding energy. In this work, we synthesize a Cerium oxide/GO composite and examine its impact on mutant and non-mutant SOD1 proteins, as well as antioxidant assays (SOD3), anti-microbial activity, and CV analysis.

Cerium oxide/GO nanocomposite; CV; Molecular docking; superoxide dismutase ( SOD1)

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