Abstract

Saad Shaaban^1,2*, Ahmed A. Al-Karmalawy³, Abdulrahman G. Alhamzani⁴, Mortaga M. Abou–Krisha^4,6, Mahmoud A. Al–Qudah^4,5 and Tarek A. Yousef^4,6

DOI : http://dx.doi.org/10.13005/ojc/390412

Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The structures of the novel compounds were elucidated by 1H-, 13C-NMR, and MS analyses. Furthermore, molecular docking analysis was performed to study the potential inhibition of the SARS-CoV-2 main protease (Mpro) by the new thiazo-isoindolinediones. The present study revealed that the new thiazo-isoindolinediones could inhibit the Mpro and represent a promising platform for the experimental development of new antiviral drugs based on thiazo-isoindolinedione scaffolds.

Condensation; COVID-19; Isoindolinedione; Molecular docking; Thiazolidinedione

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