ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Molecular Docking Studies, Synthesis of Novel Isoxazole Derivatives from 3-Methoxy Substituted Chalcone and Evaluation of their Anti-Inflammatory Activity

Sonu1*, Girendra Kumar Gautam2, Arun Kumar Mishra3, Baby Rabiya Parveen3 and Harpreet singh1

DOI : http://dx.doi.org/10.13005/ojc/390318


Abstract:

Synthesis of 3-methoxy acetophenone with substituted benzaldehydes resulted in a number of novel chalcones. The chalcones were then treated to a cyclization reaction with hydroxylamine hydrochloride in ethanol to enable the synthesis of 3-methoxy acetophenone isoxazole derivatives. After purification, the structures of the synthesized compounds were identified using TLC, FTIR, 1H NMR, 13C NMR and a Mass spectroscopy. The carrageenan-induced paw edema method was used to test the compounds for anti-inflammatory activity. Based on the findings, the three compounds appeared to be moderate to extremely active.

Keywords:

Anti-inflammatory activity; Chalcones; Hydroxylamine hydrochloride; Molecular Docking

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