Abstract

Sepideh Yadegarian, Abolghasem Davoodnia* and Ahmad Nakhaei

DOI : http://dx.doi.org/10.13005/ojc/310173

Nano-Fe₃O₄ encapsulated-silica particles bearing sulfonic acid groups (Fe₃O₄@SiO₂-OSO₃H) has been used as an efficient and magnetically separable heterogeneous catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by one-pot, four-component reaction of benzil, aromatic aldehydes, primary amines, and ammonium acetate under neat conditions. The effect of various reaction parameters, such as reaction temperature, catalyst loading and solvent effect, were studied. The desired products are obtained in relatively short reaction times with high yields. Importantly, the catalyst could be easily separated from the reaction mixture by a permanent magnet and reused for several times without the significant loss of its activity.

Fe3O4@SiO2-OSO3H; Magnetically separable; Solvent-free conditions; 1;2;4;5-Tetrasubstituted imidazoles

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