Abstract

Sumita Kumari^1*, Amit Sharma¹ and Sonia Yadav²

DOI : http://dx.doi.org/10.13005/ojc/390304

By combining of benzene nucleus and pyrone ring a class of heterocyclic compounds known as benzopyrone is generated. As a basic parent scaffold 1,2- benzopyrone ring system contains by coumarins. These compounds can be divided into two groups: 1. Benzo-α-pyrone 2. Benzo-γ-pyrone. Data on different coumarin derivatives are gathered in this review article as these compounds have a wide spectrum of pharmacological actions and can be further modified to make more potent and effective medications. Derivatives of coumarin play a significant role in industries and sectors of medicine. This can be linked to their variety of chemical characteristics and multiple biological activities. Coumarin based derivatives has a phenolic hydroxyl group which is generated as one of the most derivative functional groups. The focus of this systematic and comprehensive review on synthetic pathway of coumarin affiliates and their biological activities or potential. According to authors this review could help to medicinal chemists to choose appropriate functional group for development of novel therapeutic drugs.

Antimicrobial; Antineoplastic; Coumarin; Hepatotoxic; Neuroprotective; Pharmacological;

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