Abstract

Priyanka Yadav^1*, Arun K Mishra², Harpreet Singh³

DOI : http://dx.doi.org/10.13005/ojc/390330

Diarrhea is a symptom experienced by nearly everyone, generally considered an increase in the volume, fluidity, and/or frequency of stools. Chronic diarrhea may affect ~ 5% of people in industrialized countries, and acute or chronic infectious diarrhea remains an important cause of morbidity and mortality in developing countries. The Crassulaceae family of plants includes the Bryophyllum pinnatum (Lam.) Oken plant, which is well renowned for its therapeutic properties. The main aim of the research is to assess the antidiarrheal property using Mgso4 induced diarrheal model and isolate an active compound. Both EAE and EE exhibited consistent effects. The Percentage of Inhibition of T1 (EE 200mg/kg), T2 (EE 400mg/kg), T3 (EAE 200mg/kg) and T4 (EAE 400mg/kg) groups was found 41.51%, 61.32%, 32.56% and 52.78% respectively with standard Loperamide drug (at 3 mg/kg dose, p.o.). T2 (EE 400mg/kg) showed better outcomes because of isolated flavonoid substance, 4ʹ, 5, 7-trihydroxy flavones as a yellow pigment from ethanol-DCM, With the aid of analysis using UV, IR, NMR and mass spectroscopy, the substance, was characterized and identified as 4ʹ, 5, 7-trihydroxy flavones, with the chemical formula C15H10O5 from EE extract of Bryophyllum pinnatum (Lam.) Oken plant leaves. Finally, it can be concluded that flavonoids are responsible for the antidiarrheal activity and this may be used to determine the precise function of herbal medicine in contemporary society.

Antidiarrheal activity; Bryophyllum pinnatum Lam. (Oken); Ethanol extract; Ethyl acetate extract; Flavonoid

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