Abstract

Manishkumar Jinabhai Tank, Navinkumar A. Kucha, Chirag G. Naik, Tina R. Barot
, G. M. Malik^1*

DOI : http://dx.doi.org/10.13005/ojc/390219

Target molecules based on Adamantane-pyrido[2,3-d]pyrimidine derivatives were prepared. Adamantane-pyrido[2,3-d]pyrimidine series using N-(hydroxyadamantan-1-yl)-5-(2,4-substitutedphenyl)-2-Methyl-4-Oxo-7-(2-oxo-2H-Chromen-3-yl)pyrido[2,3-d]Pyrimidine-3(4H)carboxamide (6a-j) was synthesized by reaction between 3-(2-chloroacetyl)-5-(2,4-substitutedphenyl)-2-Methyl-7-(2-Oxo-2H-Chromen-3-yl) pyrido[2,3-d]pyrimidin-4(3H)-one (5a-j) and 3-aminoadamantan-1-ol. These derivatives of Adamantane-pyrido[2,3-d]Pyrimidine were investigated in vitro for their biological characteristics against the strains which were isolated clinically and confirmation of their structure was done by FTIR, 1H-NMR, 13C NMR and LCMS. The newly synthesized derivatives gave promising antimicrobial activity.

Adamantane, pyrido[2,3-d]pyrimidine; antimicrobial, antifungal; 3-aminoadamantan-1-ol; Chromene; N-hydroxy adamantan-1-yl; pyrido[2,3-d]pyrimidine; Pyrimidine

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