Abstract

Karuna Chourasia^1*, Bhanu Pratap Prajapati², Mithun Kori¹, Kaushal Kumar¹ and Ritu Yadav¹

DOI : http://dx.doi.org/10.13005/ojc/380628

Schiff bases are aldehyde or ketonic-like compounds in which an imine group replaces the carbonyl group and has been synthesized by condensing primary amines with an active carbonyl compound. Synthesis of two new Schiff base (NE)-N, 2-bis (2-methoxybenzylidene) hydrazine-carbothioamide and (2E)-N, 2-bis (3methoxybenzylidene) hydrazine- carbothioamide by Thiosemicarbazide with 2 methoxy benzaldehyde and 3 methoxy benzaldehyde via a condensation reaction. Metal complexes of synthesized Schiff bases have been synthesized via these Schiff base ligands with different metal ions. (Cu2+, Ni2+, Fe2+, Co2+etc) These compounds have been synthesized by the reflux method and characterized by a Spectroscopic Technique i.e., FT-IR, UV, 1H-NMR, and Mass (HRMS). The structure of the ligands was clarified by spectral studies which indicate the presence of two or four coordinating groups in ligands. Antimicrobial strain Bacillus subtilis fungi Aspergillus Niger is used for testing the antimicrobial activity. Results also indicate that the metal complexes are expected to be more biologically active as compared to the precursor. The structure of the ligands was clarified by the above spectral studies, which indicates the presence of two or four coordinating groups in ligands.

Antimicrobial activity; Benzaldehyde; Schiff base; Spectroscopic technique; Thiosemicarbazide

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