Abstract
Synthesis and pharmacological evaluation of newer substituted 2-oxo/thiobarbiturinylbenzoxa/thiazepine derivatives as potent anticonvulsant agents.
MirdulaTyagi* and Archana
DOI : http://dx.doi.org/10.13005/ojc/310113
Abstract:
A new series of 4-(2'-Oxo/thiobarbiturinyl)-2-(substitutedphenyl)-3-[(substitutedaminomethylene)]-2,3-dihydro-1,5-benzothiazepines (5a-5l) and 4-(2'-oxo/thiobarbiturinyl)-2-(substituted-phenyl)-3-(substitute daminomethylene)]-2,3-dihydro-1, 5- benzoxazepines (6a-6l) were synthesized. All the newly synthesized compounds were screened in vivo, for their acute toxicity and anticonvulsant activity in MES and PTZ models and were compared with standard drugs phenytoin sodium and sodium valporate. Out of the compounds studied, the most active compound of this series was 5 h, showed activity (90%) more potent than the standard drug.
Keywords:series; thiobarbiturinyl; substitutedphenyl)-3-[(substitutedaminomethylene)
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