Abstract

Ujjwal Das

DOI : http://dx.doi.org/10.13005/ojc/380305

Transition metal mediated thiolato compounds are highly vulnerable for S-centered oxidation due to its high nucleophilicity and which is immensely important in the point of its bio-activity. It is generally noticeable that a range of chemical changes occurred with molecular O2 and ruthenium thiolato metalloligands in varying conditions. These oxygenations are facile under strictly oxygen environment and produce mono and di sulfenato and/or sulfinato depending on the substrate thiolato. The numerous heteroatomic substituents of thiolato-S ligand have performed a vital task during the course of oxygenation producing oxygenated products as sulfenates, sulfinates and sulfones. There appear to be numerous mechanisms that are involved in the oxygenation process are considerably more complex. Some bizarre photo-induced S-center oxygenation of metal-thiolato to the sulfonated compound is also mentioned. The ruthenium sulfur compounds jointly with the S-oxygenates show remarkable bioactivity as well as enzymatic catalytic activity and interaction with the bio-molecules like DNA that opens a new theme for the researcher for design novel Ru-sulfur-oxygenates compounds as metallodrugs.

DNA binding; Dioxirane; Hydrogenase; Metallodrugs; Sulfenato; Sulfinato

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