Abstract

Dwi Hudiyanti^1*, Tri Joko Raharjo², Narsito Narsito²,  and Sri Noegrohati³

DOI : http://dx.doi.org/10.13005/ojc/310152

Leakage phenomena on sesame (Sesamum indicum L.) and coconut (Cocos nucifera L.) liposomes has been studied to evaluate their ability as drug delivery materials. Permeation of carboxyfluorescein through the liposomes with and without added cholesterol was examined. Sesame liposomes release carboxyfluorescein less than coconut liposomes in all circumstances. Sesame liposomes save about 50% of payload after 17 hours of storage while coconut liposomes only 10%. Addition of cholesterol has increase storage capability of all liposomes. The sesame-cholesterol and coconut-cholesterol liposomes save greater amount of payload compare to the original. Sesame liposomes have better potency as drug delivery systems.

coconut; cholesterol; drug delivery; leakage; liposome; sesame

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