Abstract

Sonia Yadav^1* and Nitin Kumar²

DOI : http://dx.doi.org/10.13005/ojc/370517

Coumarins are well known for their significant biological potential against several onsets. A series of novel 4-hydroxycoumarin substituted derivatives were synthesized and screened for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeureginosa bacterial strains. The zone inhibition was observed against 10 µL against different for each compound. The outcomes of the study showed that out of 10 synthesized compounds, compound 4a, 4b, 4h, and 4j showed most significant inhibitory potential against different microbial strains. The zone of inhibition for compound 4a and 4b was found as 6.36 ± 0.162, 5.60 ± 0.049, 3.61 ± 0.176, 5.64 ± 0.021 and 7.29 ± 0.339, 5.53 ± 0.459, 3.35 ± 0.226, 5.55 ± 0.042 mm while compound 4h and 4j exhibited 7.10 ± 0.544, 5.11 ± 0.183, 3.95 ± 0.226, 4.94 ± 0.494 and 6.46 ± 1.725, 4.53 ± 0.261, 3.83 ± 0.791, 5.40 ± 0.049 mm, respectively.

Antibacterial activity; 4-aminocoumarin derivatives; Coumarin; Spectral analysis

[ View HTML Full Text]