Abstract

Y.B. Nagamani², K. Hussain Reddy^1*, K. Srinivasulu¹, D. Dhanalakshmi¹ and K. Anuja¹

DOI : http://dx.doi.org/10.13005/ojc/370516

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

Antibacterial activity; DNA binding constants; New Metallo-hydrazones; Spectral characterization

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