Abstract

Subrata Paul¹, Labani Barai², Faruk Husen³, Sabarni Sarker⁴, Tarun Kumar Pal⁵, Puja Bal⁶, Md. Abdul Matin Sarker⁷, Syeda Saima Alam⁸ and Sheta Biswas^9*

DOI : http://dx.doi.org/10.13005/ojc/360621

Ranitidine is a histamine-2 receptor blocker and it is effective against peptic ulcer, gastroesophageal reflux disease and heart burn. The main objective of this study was to develop and validate an easy, affordable and cost-effective method for the determination of ranitidine in tablet dosage form. The development and validation study was performed under the guidance of ICH and USP. Results showed that the proposed validated method has good accuracy with % RSD of 0.60. Repeatability and intermediate precision suggested good precision whereas the value of correlation coefficient 0.9999 confirmed about the linearity of the method. The system suitability data and similarity factors were also found within the permissible range. The specificity study revealed that there was no placebo and diluent effect on the absorbance. Further, stability study of analytical solutions as well as estimation of drug content from market products were also performed.

Accuracy; Linearity; Method Validation; Ranitidine; Uv-Spectrophotometer

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