Abstract

N. Rama Jyothi^1,2, N.A. Mohamed Farook¹, Jaya Madhuri³ and K. Gowthami ³

DOI : http://dx.doi.org/10.13005/ojc/360615

In Coordination chemistry metal chelating agents has a vital role, among them thiosemicarbazones occupies an important place due to their a range of applications in different fields, such as analytical and biological. In the literature we can find many thiosemicarbazones which has a wide range of applications both in pharmacy and chemical fields. But still there is a scope is there to synthesize new thiosemicarbazone ligands and their metal complexes due to their utility is still there in modern chemistry also. In this present study we synthesized the copper(II) complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthiosemicarbazone, and 2-thiophenecarboxalde -hyde-4-methylthiosemicarbazone and these complexes are characterized with FT-IR, XRD analysis and thermal stabilities of the both ligands and complexes are compared with thermogravimetric analysis studies. Finally, the antibacterial activities of both chelating agents and their metal complexes are tested with two gram positive bacterial stains, such as Bacillus subtilis, Staphylococcus aureusand two gram negative bacterial stains, Pseudomonas aeruginosa, Escherichia coli.

Antibacterial Studies; Copper(II) Complexes; 9H-Carbazole-3-Carbaldehyde-4-Phenylthiosemi Carbazone; 10-Hexyl-10-H-Phenothiazine-3-Carbaldehyde-4-Phenyl Thiosemicarbazone; 2-Thiophenecarboxaldehyde-4-Methylthiosemicarbazone

[ View HTML Full Text]