Abstract

Rajendran Kumar and Subban Ravi^*

DOI : http://dx.doi.org/10.13005/ojc/360609

The synthesis of 5-benzylidene bis-rhodanine derivatives are reported from bis-rhodanine (III) and different aromatic aldehydes (IV) via Knoevenagel condensation reactions. All the Derivatives (V) and (Va-m) were deep-rooted by NMR spectroscopic techniques and elemental analysis. The antiproliferativestudy of the compounds on HeLa human cervical cancer cell line, K562 leukemic cell line and MDAMB231 breast cancer cell line were performed by MTT assay. Docking studies were carried out against the protein HPV 16E2 present in the HeLa cell line. It show good docking scores. The results indicate that the bis-rhodanine derivatives could serve as potential molecules for the development of new anticancer agents.

Breast Cancer Cell Line; Bis-Rhodanine; Docking Studies; Hela Cell Line; Leukemic Cell Line

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