Abstract

K. Susmitha*, Manan Bhargavi, D. Sumalatha and Alina Jyothi Joseph

DOI : http://dx.doi.org/10.13005/ojc/360404

Novel Schiff base is synthesized from 1:1condensation of thiophene 2- carboxaldehyde and 4-Amino indane. Two solid transition metal complexes (Ni and Co) are synthesized with this ligand. The structure of ligand (2-THIO- L) and its complexes are confirmed by various spectral characterization methods. 2-THIO- L and its metal complexes are tested for antibacterial activity against Staphylococcus aureus and Escherichia coli. Both show more activity against gram +ve than gram –ve bacteria. Molecular docking studies of ligand (2-THIO- L) against MAP2K6 indicated that they are potential inhibitors of carcinogenic receptors. DNA binding interactions of the Nickel and Cobalt complexes with CT-DNA in tris hydrochloride buffer at PH-7.2 are investigated using UV- Visible spectroscopy. The binding constants are in the range of 10⁵ M^-1 showed hypochromism which indicate good binding affinity towards CT–DNA.

2-THIO- L; 4-AMD; CT – DNA; DNA Binding; MAP2K6; Metal Complexes; Molecular Docking

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