Abstract

Arbind Kumar¹, Pushkar Kumar Sinha²and Devendra Prasad Roy³

DOI : http://dx.doi.org/10.13005/ojc/360333

The complexes of Nickel(II) and Zinc(II) with Schiff’s bases of thiophene-2-thiohydrazide of compositions [M(LH)₂] [M=Ni²⁺ or Zn²⁺ and LH=Acetone-thiophene-2-thiohydrazone (Hactth), Acetylacetone-thiophene-2-thiohydrazone (Hacactth), Benzaldehyde-thiophene-2-thio-hydrazone (Hbentth), Furfural thiophene-2-thiohydrazone(Hffth)]; [ML₂], [ML(H₂O)].nH₂O (n=0 or 2); [ML(NH₃)] and [ML(Py)]; [M=Ni²⁺ or Zn²⁺ and LH₂=Salicylaldehyde-thiophene-2-thiohydrazone (H₂Saltth), 2-hydroxyacetophenone thiophene-2-thiohydrazone (H₂aptth)]  have been prepared and characterized by elemental analysis, spectral (UV-UIS, IR, ¹HNMR) Studies, electrical conductance values, thermogravimetric analysis and magnetic Susceptibility measurements at room temperature. Some of the ligands as well as their Ni(II) and  Zn(II)complexes exhibit appreciable antifungal activity.

Antifungal Activity; Schiff’s Base; Spectral Studies; Thiohydrazones; Thermogravimetric Analysis

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