Abstract

L. Maleknia,^* Z. Rezazadeh Majdi

DOI : http://dx.doi.org/10.13005/ojc/300470

A series of new and commercially available polymers have been proposed as matrices for cell regeneration and proliferation for tissue engineering applications but lot of questions like interaction of scaffolds with biological systems, toxicity, in vivo studies etc. have to be thoroughly investigated before the technology can be used for any real practical biomedical application .In this Study gelatin nanofibers were prepared via electrospinning using aqueous solutions of formic acid/water as the solvent instead of cylotoxic solvents. The parameters, such as electric field, concentration of solutions and spinning distance were examined for studying the effects on electrospinability and morphology of gelatin nanofibers mats.Gelatin solutions with various concentrations of gelatin (20%–30%, w/v) were prepared using concentrated aqueous formic acid/water with ratios (100/0, 75/25, 50/50 and 75/25, %v/v) as solvent at room temperature.Morphology of nanofibres was examined by scanning electron microscopy and diameter, diameter distribution and uniformity were measured with image analyzer software. The lowest diameter of gelatin nanofibers (197 nm) was achieved when the gelatin concentration was 20%.The results showed that the spinability of gelatin strongly depend on the solvent used.

Gelatin-Acid Formic-Nano Fiber-Electrospinning

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