Abstract

Reham Faek Hameed, Areej Ali Jarullah* and Fadhil Lafta Faraj

DOI : http://dx.doi.org/10.13005/ojc/350342

In this research, new ligand (LBe) 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e] indol-2-ylidene) propane-1,3-diylidene) bis(azanylylidene) diphenol was synthesized by the condensation reaction of 2-hydoxy aniline with 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde (Be) in ratio 2:1. (LBe) was used as ligand to synthesis a series of metal complexes by its reaction with different metal chlorides in a molar ratio 1:1 and 1:2 of M:L in ethanol such as (NiCl2.6H2O, CuCl2.2H2O, CoCl2.6H2O, MnCl2.4H2O and ZnCl2). The chemical structures of the ligand and its complexes were characterized by 1H-NMR spectroscopy, infrared spectroscopy, ultra violet-visible spectroscopy, magnetic susceptibility, and molar conductivity measurements. According to the results obtained the suggested structures of the complexes, Square planar geometry for [Co(LBe)], [Ni(LBe)], [Cu(LBe)], octahedral geometry for [Mn(LBe)] and tetrahedral geometry for [Zn(LBe)2]. Cytotoxicity effect of ligand LBe and its complexes have been evaluated against Hella cell line (cervical cancer) in two exposure times 24 and 48 hrs.

Hella Cell Line; 2-Hydoxy Aniline; LBe Ligand, Metal Complexes

[ View HTML Full Text]